Our laboratory has an interest and expertise in elucidating gene expression programs involved in tumorigenesis, especially those involving cells in the tumor microenvironment. To do this, we use transgenic mouse models, "omic" technologies such as single cell sequencing and mass spectrometry, as well as the culture of primary and cancer cells. In addition, we are developing molecules (antisense oligonucleotides) to reduce tumor growth in pre-clinical models.